Bioactive Small Molecules
Medchemexpress LLC HY-107004A 5mg , Amotosalen (hydrochloride) CAS:161262-45-9 Purity:>98%
HY-107004A 5mg Amotosalen (hydrochloride) CAS: 161262-45-9 Amotosalen hydrochloride (S-59) is a light-activated, DNA-, RNA-crosslinking psoralen compound, which is used to neutralise pathogens. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-103080 5mg , CMF019 CAS:1586787-08-7 Purity:>98%
HY-103080 5mg CMF019 CAS: 1586787-08-7 CMF019 is a potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents. Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
TARGETMOL CHEMICALS INC HPGDS inhibitor 1 5mg
HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM.
Medchemexpress LLC Irinotecan | 97682-44-5 | MFCD00866307 | 10 mM * 1 mL in DMSO
Irinotecan | Putity: 99.84% | MW: 586.68 | 97682-44-5 | MFCD00866307 | 10 mM * 1 mL in DMSO
Medchemexpress LLC Erlotinib | 183321-74-6 | MFCD02089651 | 10 mM * 1 mL in DMSO
Erlotinib | Putity: 99.99% | MW: 393.44 | 183321-74-6 | MFCD02089651 | 10 mM * 1 mL in DMSO
Medchemexpress LLC VO-Ohpic trihydrate | 476310-60-8 | 98.0% | 50 MG
VO-Ohpic trihydrate is a highly potent inhibitor of PTEN with an IC50 of 46±10 nM. This sterically demanding molecule significantly inhibits PTEN activity even at low nanomolar concentrations. It is recognized as a specific and potent PTEN inhibitor, and is considered the most potent inhibitor of PTEN lipid phosphatase activity.
- Highly potent inhibitor of PTEN with an IC50 of 46±10 nM
- Significantly inhibits PTEN activity at low nanomolar concentrations
- Specific and potent PTEN inhibitor
- Most potent inhibitor of PTEN lipid phosphatase activity (IC50 of 35 nM)
Medchemexpress LLC N3-PEG4-C2-NHS ester | 944251-24-5 | 98.9% | 500 MG
N3-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker designed for the synthesis of antibody-drug conjugates (ADCs). This versatile click chemistry reagent features an Azide group, which allows it to readily engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Furthermore, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when combined with molecules containing DBCO or BCN groups, offering flexibility in conjugation strategies. This product is suitable for research applications.
- Non-cleavable PEG linker for stable conjugation.
- Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions.
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- Designed for the synthesis of antibody-drug conjugates (ADCs).
- Intended for research use only.
Medchemexpress LLC Torin 2 | 1223001-51-1 | 99.65% | 1 ML
Torin 2 is an mTOR inhibitor with an EC50 of 0.25 nM for inhibiting cellular mTOR activity. It exhibits 800-fold selectivity over PI3K (EC50: 200 nM) and also inhibits DNA-PK with an IC50 of 0.5 nM in the cell-free assay. Torin 2 can suppress both mTORC1 and mTORC2.
- Potent mTOR inhibitor with an EC50 of 0.25 nM for cellular mTOR activity.
- Exhibits 800-fold selectivity over PI3K.
- Inhibits DNA-PK with an IC50 of 0.5 nM in cell-free assays.
- Suppresses both mTORC1 and mTORC2.
- Demonstrates good bioavailability and exposure in vivo.
- Possesses improved pharmacokinetic properties for in vivo experiments.
- Maintains strong inhibition of mTOR activity in lung and liver for extended periods.
Medchemexpress LLC FITC-Dextran | 60842-46-8 | 100 MG
FITC-Dextran (MW 500000) is a fluorescent dye utilized in biomedical research as a tracer molecule. It combines fluorescein isothiocyanate (FITC) with dextran, a carbohydrate, to form a stable fluorescent tracer. This allows for labeling and tracking cells or other biological matter, visible under microscopy or quantifiable with specialized detection instruments.
- Acts as a fluorescent probe (Ex=495 nm; Em=525 nm)
- Can reveal heat shock-induced cell damage
- Supports studies on early and late stages of apoptosis
- Suitable for cell permeability studies
- Assesses blood-brain barrier disruption
Medchemexpress LLC VBIT-4 | 2086257-77-2 | 99.3% | 100 MG
VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. It acts as an apoptosis inhibitor and can be used for therapeutic purposes in apoptosis-associated disorders such as neurodegenerative and cardiovascular diseases. It targets the mitochondrial protein VDAC1, inhibiting apoptosis and protecting against mitochondrial dysfunction.
- Inhibitor of VDAC1 oligomerization
- Apoptosis inhibitor
- Protects against mitochondrial dysfunction
- Can be used for therapeutic purposes in apoptosis-associated disorders
Medchemexpress LLC Ebsulfur | 2527-03-9 | 99.4% | 50 MG
Ebsulfur is a benzisothiazolone cytocidal inhibitor that targets the trypanothione reductase (TryR) of *Trypanosoma brucei*. It is used for research on African trypanosomiasis.
- Targets trypanothione reductase (TryR) of *Trypanosoma brucei*
- Has IC50 values of 61-293 nM for *Trypanosoma brucei*
- Used for research on African trypanosomiasis
Medchemexpress LLC PI3K/mTOR Inhibitor-4 | 2361215-32-7 | 97.0% | 100 MG
PI3K/mTOR Inhibitor-4 is an orally active pan-class I PI3K/mTOR inhibitor. It exhibits enzymatic inhibition activity for PI3Kα, PI3Kγ, PI3Kδ, and mTOR with IC50 values of 0.63 nM, 22 nM, 9.2 nM, and 13.85 nM, respectively. This inhibitor is suitable for cancer research and shows potent anti-proliferation activity in various cell lines.
- Orally active pan-class I PI3K/mTOR inhibitor
- Enzymatic inhibition of PI3Kα, PI3Kγ, PI3Kδ, and mTOR
- Suitable for cancer research
- Potent anti-proliferation activity in various cell lines
- Inhibits PI3K/AKT/mTOR pathway
- Low toxicity in PC12 and LO2 cells
- Decreases phosphorylation of AKT and S6 in Hela cells
- Favorable pharmacokinetic parameters in rats
- Effective in tumor xenograft models
- Soluble in DMSO (250 mg/mL)
Medchemexpress LLC 6-hexadecenoic acid, sodium salt (1:1), (6Z)- | 217477-25-3 | 98.0% | 1 ML
Sapienic acid sodium is a fatty acid commonly found on the skin and in mucosa, possessing variable antimicrobial activities against both Gram-positive and Gram-negative bacteria. It is active against Streptococcus sanguinis, Streptococcus mitis, and Fusobacterium nucleatum.
- Found naturally on skin and mucosa.
- Exhibits antimicrobial activity against various bacteria.
- Active against specific Gram-positive and Gram-negative bacteria.
- Soluble in ethanol for in vitro applications.
Medchemexpress LLC IL-6 Pig 20ug
IL-6 protein is a multifunctional cytokine that participates in immune regenerative and metabolic processes by binding to IL6R and forming a complex with IL6ST/gp130 This activates the IL6 signaling pathway initiating classical signaling via membrane-bound IL6R and IL6ST trans signaling via binding of IL6 and soluble IL6R to IL6ST and cluster signaling via the IL6 IL6R complex IL-6 Protein Pig is the recombinant pig-derived IL-6 protein expressed by E coli with tag free